COMT gene mutation | Pro Health Medicine

If you carry the slow COMT gene mutation, specifically the Met/Met variant, your body processes dopamine and norepinephrine much more slowly than average. This difference in how your brain handles these neurotransmitters means that medications to treat ADHD, depression, narcolepsy, and chronic pain, which increase their levels, can cause serious side effects.

Why Individuals with Slow COMT Gene Should Steer Clear of Some Medications for ADHD and Depression

Understanding your COMT gene status empowers you to make informed decisions about medications like NRIs. If you have the slow COMT variant, avoiding NRIs can prevent serious side effects and support a calmer, healthier brain function. Genetic testing combined with lifestyle changes offers a path to better mental health tailored to your unique biology.

Kristina Reynolds

May 43 min read

The COMT gene plays a crucial role in how our bodies manage key brain chemicals like dopamine, epinephrine, norepinephrine, and estrogen. Variations in this gene affect the activity of the catechol-O-methyltransferase enzyme, which breaks down these substances.

Is Stress in Your DNA: How COMT Gene Mutation Impact Mental Health and Stress Responses

These differences can influence how people respond to stress, their cognitive abilities, and their risk for conditions such as anxiety, ADHD, and schizophrenia. Understanding these variations helps explain why some people handle stress better or worse than others and why mental health symptoms can vary widely.

Kristina Reynolds

Apr 224 min read